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KMID : 0362420080460040335
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Journal of Korean Academy of Prosthodontics
2008 Volume.46 No. 4 p.335 ~ p.342
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Comparison on New Bone Formation Between Ovariectomized Rats and Normal Rats After Graft of Alloplastic bone material
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Lee Jong-Won
Ryu Jae-Jun
Ahn Jin-Su
Ahn Jae-Seok
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Abstract
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Purpose of study: To compare on bone formation between ovariectomized rats and normal rats after graft of alloplastic bone material.
Material and methods: Twenty female rats were used in this study. They were divided into two groups by each ten rats. One group was ovariectomized and grafted alloplastic bone material. Other group was non-ovariectomized and grafted alloplastic bone material. After a healing time of 4 weeks, the animals were sacrificed and decalcified preparations were routinely processed for histologic evaluations.
Results: Ovariectomy group was significantly lesser bone formation compared with non-ovariectomy group.
Conclusions: Ovariectomy acts as a negative factor in new bone formation.
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KEYWORD
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Ovariectomy, New bone formation, Critical sized defect
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